Ive seen lots of guys doin it. you may need to crank your torsion bars a little and/or trim the corner of your lower valance.
I had an 05 2500 gasser and just adjusted the torsion bars abit. Then you have to have you alignment done.
I know this is kinda late but I am running 285/75-16's with no lift and no turns on my bars. All I did was trimmed the front valance and pulled back the fender lining so that it doesn't rub. I haven't had any issues at all and I pull my toyhauler offroad all the time. They are also mounted on the stock PYO's. If you are going to run a wider wheel and or tire then maybe you will have to crank or level it.
Gees, I need to get online more often....haha. The 285's are the Nitto Terra Grapplers and they are doing great. I have 14k on them right now and they look close to new. I don't drive too hard and no burnouts. I really like the looks of going to the bigger tire. Oh and with my predator on 65 I am still getting 18 mpg daily driving and around 22 hwy.